The Executive Director, Global Projects Leader (GPL) - Strategic Regimens (Lung) will have overall leadership and accountability of multiple, global cross-functional early project teams delivering platform studies with embedded translational medicine research to establish proof-of-concept data enabling Phase III investment strategies. Each team will aim to prioritize and evaluate rational combination regimens across major AZ research platforms and treatment modalities and with the potential for external partnering. This individual will be accountable for the strategic leadership and execution for candidate combination regimens, aligning prioritization across early- and late-stage research units to advance the Lung Cancer pipeline. You will have oncology clinical drug development experience, demonstrated leadership, and be able to critically evaluate the science, clinical data and competitive landscape that underlies each program. You will be able to effectively communicate across a broad range of audiences and have an ability to clearly articulate project-specific strategies and deliverables as it relates to the overall AZ and Early Oncology vision.

Leads global matrix teams that develop and execute Ph2 platform studies evaluating combination regimens through proof of concept leading to Phase III investmentResponsible for ongoing linkage between early- and late-stage Oncology R&D teams to develop novel regimens with transformational potential and to maximize value of each assetHolds accountability for the strategy, budget, timeline and execution of platform studies and Ph3 supporting data generation  Ensures platform studies support life cycle management strategies and integrated product development plans of AZ’s emerging portfolioLeads and communicates the project development strategy at governance meetings to gain endorsement and to secure fundingLeads the global project team to effectively communicate and manage risk; responsible for monitoring emerging data and for adjusting strategy when necessaryResponsible for maintaining a high degree of team effectiveness through collaboration, influence, and, as necessary, coaching and mentoring of cross-functional team membersMaintains relationships with external investigators to ensure projects are consistent with evolving clinical care and experimental approaches

Essential

Graduate degree such as MD/PhD 10yrs or moreIndustry experience in drug development including experience in early phase clinical drug development and regulatory knowledgeStrong knowledge and understanding of the Oncology therapeutic area with experience in diverse biological modalitiesUnderstanding of the evolving clinical landscape in oncology, with a focus in lung cancerDemonstrated experience leading and motivating teams in a highly matrixed environmentProven record of cultivating and managing internal and external cross-functional collaborationsDemonstrated success in influencing colleagues and senior leaders in various departmentsMust demonstrate high integrity

Desirable

Experience in development of both small molecules and biologics, including ADCs and/or IO (Immune Checkpoint Inhibitors)Experience in the development of platform studiesExperience developing data and justification leading to successful Ph3 investment decisionsExperience in due diligence (e.g. asset evaluation, assessment of new biomarker and diagnostic tools)Demonstrated experience leading and motivating teams in a highly matrixed environmentProven record of cultivating and managing internal and external cross-functional collaborationsDemonstrated success in influencing colleagues and senior leaders in various departmentsMust demonstrate high integrity

Date Posted

29-Apr-2025

Closing Date

29-Jun-2025Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.