**Job Title:** Senior Scientist- Vaccines **Location** : Swiftwater, PA **About the Job** The Senior Scientist for CMI &Automation team will design, develop, qualify, validate, and interpretate cellular immunology methodologies to characterize functional T-cell and B-cell subsets and innate immunity for sample analysis for clinical studies across the Sanofi vaccine portfolio We are an innovative global healthcare company that helps the world stay ahead of infectious diseases by delivering more than 500 million vaccine doses a year. Across different countries, our talented teams are exploring new technologies to protect people and promote healthy communities. We chase the miracles of science every single day, pursuing progress to make a real impact on millions of patients around the world. **Main Responsibilities:** + In addition to deep immunological expertise, the candidate will be expected to provide mentorship and effectively supervise and train lab personnel to perform assigned tasks while ensuring applicable compliance and regulatory agency standards are met. + The candidate will serve as key resource as expert technical representation within its organization and on multidisciplinary teams. + It is expected the candidate remain current on state-of-the art technologies such as high dimensional spectral cytometry and embrace the evaluation of new technologies and automation. **About You** **Requirements** **Education/experience** + Specialized degree in biological sciences from an accredited University + B.Sc. + 8 yr experience + M.Sc. + 5yr experience + PhD + 1yr experience + Demonstrated expertise examining antigen-specific immune cell function through in vitro/ex vivo stimulation of human primary PBMCs for intracellular cytokine staining analysis (ICS) as evidenced by scientific publications and presentations at scientific meetings + In depth knowledge and hands on experience with immunological phenotypic and ICS analysis of multiple cell lineages using multi-parameter flow cytometry and qualification/validation of such assays as well as their downstream analyses and reporting. + Ability to work with viruses, bacteria and potentially infectious samples from humans (BSL-2 or BSL-2+) + Lead, mentor and train lab staff + Strong ability to deliver complex objectives under aggressive timelines in a rapidly changing environment + Excellent technical, critical thinking and communication (oral and written) skills with ability to manage projects and resolve technical problems independently and also work effectively within cross-functional teams + Experience working in GXP compliant environment. **Functional/Technical Skills** + Extensive hands-on experience with human PBMC isolation/cryopreservation and culture and treatment of primary cells + Experience in design, execution and troubleshooting of 22+ colour flow cytometry panels for immunophenotypic and ICS analysis using Cytek Aurora + In-depth knowledge of various immune subsets + Considerable experience in the use of flow cytometry analysis software OMIQ + Strong laboratory experience and understanding of clinical and non-clinical flow cytometry assay development, validation and implementation + Understanding of GXP practices and procedures required. **Preferred experience and skills:** + Hands-on experience with liquid handlers and end-to-end automation + Knowledge of bioinformatics and statistical analysis is desirable + Hands on experience with high-dimensional data analysis (e.g. tSNE, UMAP, CITRUS, FlowSOM) + Hands on experience with automated data analysis including sample QC during clinical testing + In-depth understanding of the vaccine development process and comprehensive knowledge of the principles and concepts of immunogenicity assay validation, clinical testing and regulatory submission for regulated vaccine bioanalytical assays and strategies + Be a highly motivated team player with the ability to interact effectively within a multi-disciplinary team **Why Choose Us?** + Bring the miracles of science to life alongside a supportive, future-focused team. + Discover endless opportunities to grow your talent and drive your career, whether it’s through a promotion or lateral move, at home or internationally. + Enjoy a thoughtful, well-crafted rewards package that recognizes your contribution and amplifies your impact. + Take good care of yourself and your family, with a wide range of health and wellbeing benefits including high-quality healthcare, prevention and wellness programs and at least 14 weeks’ gender-neutral parental leave. Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law. \#GD-SP ​ \#LI-SP \#LI-Onsite \#vhd **Pursue** **_progress_** **, discover** **_extraordinary_** Better is out there. Better medications, better outcomes, better science. But progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let’s be those people. At Sanofi, we provide equal opportunities to all regardless of race, colour, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, ability or gender identity. Watch our ALL IN video (https://www.youtube.com/watch?v=SkpDBZ-CJKw&t=67s) and check out our Diversity Equity and Inclusion actions at sanofi.com (https://www.sanofi.com/en/our-responsibility/equality-and-inclusiveness) ! _US and Puerto Rico Residents Only_ Sanofi Inc. and its U.S. affiliates are Equal Opportunity and Affirmative Action employers committed to a culturally inclusive and diverse workforce. All qualified applicants will receive consideration for employment without regard to race; color; creed; religion; national origin; age; ancestry; nationality; natural or protective hairstyles; marital, domestic partnership or civil union status; sex, gender, gender identity or expression; affectional or sexual orientation; disability; veteran or military status or liability for military status; domestic violence victim status; atypical cellular or blood trait; genetic information (including the refusal to submit to genetic testing) or any other characteristic protected by law. _North America Applicants Only_ The salary range for this position is: $100,500.00 - $145,166.66 All compensation will be determined commensurate with demonstrated experience. Employees may be eligible to participate in Company employee benefit programs. Additional benefits information can be found through the LINK (https://benefits.sanofiusallwell.com/fleet/public/index/ba511bf8-5c32-4828-9861-ab985fffab90/?cid=sanofi) . Global Terms & Conditions and Data Privacy Statement (https://www.sanofi.com/en/careers/global-terms-and-conditions/) Sanofi is dedicated to supporting people through their health challenges. We are a global biopharmaceutical company focused on human health. We prevent illness with vaccines, provide innovative treatments to fight pain and ease suffering. We stand by the few who suffer from rare diseases and the millions with long-term chronic conditions. With more than 100,000 people in 100 countries, Sanofi is transforming scientific innovation into healthcare solutions around the globe. Discover more about us visiting www.sanofi.com or via our movie We are Sanofi (https://youtu.be/96EwNjb1TLo) As an organization, we change the practice of medicine; reinvent the way we work; and enable people to be their best versions in career and life. We are constantly moving and growing, making sure our people grow with us. Our working environment helps us build a dynamic and inclusive workplace operating on trust and respect and allows employees to live the life they want to live. All in for Diversity, Equity and Inclusion at Sanofi - YouTube (http://www.youtube.com/watch?v=SkpDBZ-CJKw&t=2s)