**Job Description** Our company is a global health care leader with a diversified portfolio of prescription medicines, vaccines and animal health products. The difference between potential and achievement lies in the spark that fuels innovation and inventiveness; this is the space where our company has codified its legacy for over a century. Our Research and Development Division in San Diego is a cross-functional team (Discovery Biologics, Immunology, and Data Science) with the goal to discover and develop novel, innovative therapeutics in the field of Inflammation and Immunology. The Discovery Biologics Department is seeking a Senior Scientist with expertise in antibody expression and production workflows. This position offers a great opportunity to be a part of the early scientific team, and a key interface within global Discovery Biologics network and with Immunology and other functions across our company. The successful candidate will carry out experiments in the lab to build and support projects in the early discovery pipeline, with focus on antibody-based therapeutics and different mammalian expression systems. We recognize that the diversity in our team is our strength and are dedicated to creating an inclusive environment for all employees. Successful candidates should demonstrate attention to detail, ability to work efficiently and collaboratively, a desire to learn, and be adaptable to thrive in a dynamic team environment. **Key Responsibilities:** + Expressing both antibodies and target proteins in mammalian cells and other eukaryotic systems. + Executing tissue culture-based experiments, including maintaining and transfecting mammalian cell line. + Troubleshooting mammalian expression systems and Optimizing parameters to maximize protein expression levels. + Developing high-throughput mammalian cell-based production platforms for antibodies. + Exploring and applying new protein expression technologies and strategies as needed. + Running and developing analytical assays, including protein quantitation, HPLC, Western blotting, and other characterization assays. + Continuously reviewing processes, troubleshooting issues, and implementing improved workflows. + Managing day-to-day laboratory activities and ensuring the team operates efficiently. + Collaborating with other teams to integrate new developments into future projects. **Position Qualifications:** **Education:** + Bachelor’s (with 7 years), Master’s (with 4 years) or Ph.D. in molecular biology, biochemistry, structural biology or related discipline with relevant laboratory experience described below **Required Experience and Skills:** + Extensive hands-on experience with mammalian cell culture and expression platforms (CHO, HEK293) + Experience with antibody-based therapeutic modalities (mAb, VHH, bispecific Ab, antibody fusions, etc) + Expertise in cell culture process optimization to improve titer and productivity + Hands-on experience with cloning techniques, including Gibson assembly, plasmid characterization, and protein expression + Experience in designing constructs in Geneious: vector selection, cassette design, cloning and validation + Proven proficiency in protein production workflows, including purification and analytical characterization + Demonstrated strong communication skills and ability to multi-task and work collaboratively in a cross-functional team environment + Excellent organizational skills and high attention to detail **Preferred** **Experience and Skills:** + Five (5) years of hands-on experience with mammalian cell culture and expression platforms (CHO, HEK293) + Experience in stable expression systems + Experience with Mass spectrometry for antibody intact mass determination and peptide mapping + Experience with high throughput technologies and automation platforms \#EligibleforERP Current Employees apply HERE (https://wd5.myworkday.com/msd/d/task/1422$6687.htmld) Current Contingent Workers apply HERE (https://wd5.myworkday.com/msd/d/task/1422$4020.htmld) **US and Puerto Rico Residents Only:** Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please click here (https://survey.sogosurvey.com/r/aCdfqL) if you need an accommodation during the application or hiring process. As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit: EEOC Know Your Rights (https://www.eeoc.gov/sites/default/files/2022-10/22-088\_EEOC\_KnowYourRights\_10\_20.pdf) EEOC GINA Supplement​ We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively. Learn more about your rights, including under California, Colorado and other US State Acts (https://www.msdprivacy.com/us/en/CCPA-notice/) **U.S. Hybrid Work Model** Effective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”. The salary range for this role is $104,200.00 - $163,900.00 This is the lowest to highest salary we in good faith believe we would pay for this role at the time of this posting. An employee’s position within the salary range will be based on several factors including, but not limited to relevant education, qualifications, certifications, experience, skills, geographic location, government requirements, and business or organizational needs. The successful candidate will be eligible for annual bonus and long-term incentive, if applicable. We offer a comprehensive package of benefits. Available benefits include medical, dental, vision healthcare and other insurance benefits (for employee and family), retirement benefits, including 401(k), paid holidays, vacation, and compassionate and sick days. More information about benefits is available at https://jobs.merck.com/us/en/compensation-and-benefits . You can apply for this role through https://jobs.merck.com/us/en (or via the Workday Jobs Hub if you are a current employee). The application deadline for this position is stated on this posting. **San Francisco Residents Only:** We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance Ordinance **Los Angeles Residents Only:** We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring Ordinance **Search Firm Representatives Please Read Carefully** Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails. **Employee Status:** Regular **Relocation:** Domestic **VISA Sponsorship:** No **Travel Requirements:** No Travel Required **Flexible Work Arrangements:** Not Applicable **Shift:** 1st - Day **Valid Driving License:** No **Hazardous Material(s):** N/A **Required Skills:** Analytical Characterization, Antibodies, Bispecific Antibodies, Cell Cultures, Cloning Techniques, Mammalian Cell Culture, Protein Expression, Protein Purification Methods **Preferred Skills:** **Job Posting End Date:** 08/8/2025 ***A job posting is effective until 11:59:59PM on the day** **BEFORE** **the listed job posting end date. Please ensure you apply to a job posting no later than the day** **BEFORE** **the job posting end date.** **Requisition ID:** R360289