Do you have expertise within in vitro cardiovascular biology and enjoy working in the lab? Would you like to apply your expertise in a global company that is accelerating innovative science and turning ideas into life-changing medicines? Join us to discover future treatments for Cardiovascular, Renal, and Metabolic (CVRM) diseases!
CVRM is one of three main therapeutic research areas within AstraZeneca. Early CVRM has a patient-centric approach for discovering novel treatments for patients with cardiovascular, chronic kidney, and metabolic diseases and delivers candidate drugs into late-stage clinical development. In the Bioscience Cardiovascular department, we focus on identifying and validating new drug targets for the treatment of patients with cardiovascular disease and heart failure, as well as evaluating pharmacological aspects, such as efficacy and mechanism of action, of potential new drug candidates. The in vitro team delivers key data to projects across all phases of the drug discovery and development process, working with different modalities such as small molecules, modified mRNA, antibodies, cell therapy, antisense oligonucleotides, and peptides.
We are now recruiting a Senior Scientist with expertise in cardiovascular biology to join the Bioscience Cardiovascular in vitro team within the Cardiovascular, Renal, and Metabolism therapeutic area at AstraZeneca in Gothenburg, Sweden.
Accountabilities
As a Senior Scientist, you will play a key role in driving science and projects within the cardiovascular area forward. This is a lab-based role where you will explore novel drug targets with key in vitro data. Collaboration is critical for successful delivery of drug projects, and you will work closely with scientists/teams from a wide range of different functions within AstraZeneca as well as with external partners and collaborators. You will work with in vitro biology using cell lines, pluripotent stem cells (PSC), and primary cardiovascular cells along with molecular and functional biology techniques. You will have the opportunity to try novel techniques and ideas required for progressing existing portfolios and novel science. Responsibilities include:
Independently design, develop and run in vitro studies and assays for target identification and validation
Work with molecular biology methods, imaging, and assays for functional readouts such as contractility and cardiac metabolism
Contribute to communications of scientific findings through publications in scientific journals and at meetings
Proactively contribute to a vibrant and innovative working environment where improvements and new ideas are adopted and freely shared
Engage actively in project work by collaborating with Bioscience and various functions across AstraZeneca to ensure the successful execution of key project activities
Essential Skills/Experience
PhD or master’s degree in biology, pharmacology, cardiovascular disease or similar
Strong experience in cell and molecular biology, biochemistry and relevant in vitro/ex vivo assays
Minimum 2 years hands on experience in handling and manipulating relevant PSC cells and primary human and animal cardiac cell types, including cardiomyocytes
Minimum 2 years hands on experience in in vitro work within the cardiovascular field, involving endothelial cells, cardiomyocytes, and fibroblasts in both healthy and diseased cardiovascular preclinical model systems
Excellent English communication skills, both spoken and in writing
Desirable Skills/Experience
Experience with cardiomyocyte biology and function in healthy and diseased systems
Background in drug discovery and development in the pharmaceutical industry
At AstraZeneca, we are committed to making a difference. We have built our business around our passion for science. Now we are fusing data and technology with the latest scientific innovations to achieve the next wave of breakthroughs. Our inclusive environment allows us to work seamlessly together, leveraging our diverse global knowledge to create the greatest impact on disease. Here you can grow your career while contributing to life-changing medicines.
Ready to make a difference? Apply now!
Welcome with your application no later than May 11th, 2025
Date Posted
30-apr.-2025Closing Date
11-maj-2025Our mission is to build an inclusive and equitable environment. We want people to feel they belong at AstraZeneca and Alexion, starting with our recruitment process. We welcome and consider applications from all qualified candidates, regardless of characteristics. We offer reasonable adjustments/accommodations to help all candidates to perform at their best. If you have a need for any adjustments/accommodations, please complete the section in the application form.