_Le contenu du poste est libellé en anglais car il nécessite de nombreuses interactions avec nos filiales à l’international, l'anglais étant la langue de travail._ _This job offer is accessible to all, regardless of gender. _ **Job title:** _Senior Associate Scientist, Bioimaging, Immunohistology and Immunology_ + _Location: Marcy L' Etoile_ **_About the job_** As an experienced **Bioimaging Associate Scientist** , you will oversee designing, performing and optimizing _in vivo_ imaging studies to characterize mRNA-LNP formulations and to decipher mode of actions. **Main responsibilities:** + Design, perform and optimize _in vivo_ imaging studies to characterize new vaccine candidates in adequate preclinical models. Creating and developing advanced _in vitro, in vivo_ and _ex vivo_ studies utilizing nucleic acid bio-analytics, and wide range of preclinical, cell biology and optical microscopy analysis + Especially use bioimaging tools to support mRNA and Lipid Nanoparticles process Development and Optimization. Coordinate the bioimaging activities, compile the analytical data package to support advancement of mRNA and other development candidates + Design and troubleshoot protein and molecular assays for use on _in vitro_ and _in vivo_ samples including: mammalian cell transfections, ELISA, functional antibody assays, flow cytometry, reporter assays, activity assays + Design and troubleshoot cell-based methods and immunoassay methods + Critically analyze, interpret, and report experimental results; draw appropriate conclusions and design next steps. Contribute to the protocol, report writing when appropriate including reports to include in Health Authorities dossiers + Work in highly collaborative cross functional teams. Make scientific presentation and report project progress in mRNA center of excellence team meetings in both languages, English and French + Ensure timely completion of assignments and deliverables **_About you_** **Experience:** + High experience in bioimaging and animal sciences + At least 3+ years in mRNA field and 10+ years of pharma/biotech + Skilled in bioimaging and ability to perform complex method, _in vivo_ model development and propose appropriate method improvement + Experience in computerized tomography, bioluminescence and fluorescence imaging + Experience in optical imaging with IVIS Spectrum-CT, Cellvizio fibered Laser Endomicroscope and Kaer Imaging System. Able to use M3 Vision, Living Image, ICViewer, ImageJ/Fiji and KIScontrol softwares + Experience in pharmacology _in vivo_ , Surgery models, Pathophysiology , Histology and Immunohistochemistry + Management of preclinical sample and collection (blood, serum, organs, etc.) + French License on animal experimentation in biology is mandatory: FELASA category B or C + Experience in working with biosafety level 2 and 3 constraints and Specific Pathogen Free animal facilities + Experience in mammalian cell culture and transfection, ELISA, functional antibody assays and flow cytometry would be really appreciated + Proven capability of evaluating/developing new technologies + Experienced working with highly technical projects with reactivity + Able to work independently and collaborate in team, enthusiastic and self-motivated **Languages:** + Excellent verbal and written communication skills in English and French **Education:** + Bachelor’s degree or MSc/Engineer As a healthcare company and a vaccine manufacturer, Sanofi has an important responsibility to protect individual and public health. This position will require individuals to be fully vaccinated against Flu as part of your job responsibilities. **Pursue** **_Progress_** **.** **Discover** **_Extraordinary_** **.** Progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. You can be one of those people. Chasing change, embracing new ideas and exploring all the opportunities we have to offer. Let’s pursue progress. And let’s discover extraordinary together. At Sanofi, we provide equal opportunities to all regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, or gender identity. Watch our ALL IN video (https://www.youtube.com/watch?v=SkpDBZ-CJKw&t=67s) and check out our Diversity Equity and Inclusion actions at sanofi.com (https://www.sanofi.com/en/our-responsibility/equality-and-inclusiveness) ! **\#LI-FRA** **\#LI-Hybrid** **Pursue** **_progress_** **, discover** **_extraordinary_** Better is out there. Better medications, better outcomes, better science. But progress doesn’t happen without people – people from different backgrounds, in different locations, doing different roles, all united by one thing: a desire to make miracles happen. So, let’s be those people. At Sanofi, we provide equal opportunities to all regardless of race, colour, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, ability or gender identity. Watch our ALL IN video (https://www.youtube.com/watch?v=SkpDBZ-CJKw&t=67s) and check out our Diversity Equity and Inclusion actions at sanofi.com (https://www.sanofi.com/en/our-responsibility/equality-and-inclusiveness) ! Global Terms & Conditions and Data Privacy Statement (https://www.sanofi.com/en/careers/global-terms-and-conditions/) Sanofi is dedicated to supporting people through their health challenges. We are a global biopharmaceutical company focused on human health. We prevent illness with vaccines, provide innovative treatments to fight pain and ease suffering. We stand by the few who suffer from rare diseases and the millions with long-term chronic conditions. With more than 100,000 people in 100 countries, Sanofi is transforming scientific innovation into healthcare solutions around the globe. Discover more about us visiting www.sanofi.com or via our movie We are Sanofi (https://youtu.be/96EwNjb1TLo) As an organization, we change the practice of medicine; reinvent the way we work; and enable people to be their best versions in career and life. We are constantly moving and growing, making sure our people grow with us. Our working environment helps us build a dynamic and inclusive workplace operating on trust and respect and allows employees to live the life they want to live. All in for Diversity, Equity and Inclusion at Sanofi - YouTube (http://www.youtube.com/watch?v=SkpDBZ-CJKw&t=2s)