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Beacon Hill Life Sciences is seeking a Research Scientist/Sr Research Scientist with extensive expertise in mass spectrometry-based bioanalysis, protein/peptide characterization, and analytical assay development to join client's team.

The successful candidate will contribute to bioanalytical method development, validation, and large-scale study support across discovery and clinical programs, with a strong focus on LC-MS/MS (MRM), Immunoprecipitation, and complementary biochemical techniques.

Key Responsibilities:

Lead the development, optimization, and validation of LC-MS/MS assays (MRM mode) and IP assay for quantification of biomarkers, proteins, peptides, cytokines, and metabolites.Design and execute workflows for peptide mapping, post-translational modification (PTM) analysis, disulfide bond mapping, and glycosylation analysis.Develop fit-for-purpose bioanalytical methods for proteins with complex attributes (e.g., high MW, high glycosylation, unexpected MWs) using advanced enzymatic digestion strategies (deglycosylation, limited proteolysis).Support cross-functional groups including expression, reagent, and engineering teams by providing detailed biochemical and analytical characterization of proteins and reagents.Conduct advanced data processing and statistical analysis using multiple software from different vendorsInstrument maintenance and troubleshootingAuthor technical reports, SOP, Electronic notebook

Qualifications:

Minimum of 5~8 years of relevant industry experience, or 3~5 years with a PhDExtensive experience with mass spectrometry analysis of proteins and peptides (QTRAP, Q-TOF, MALDI-TOF, Orbitrap Fusion/Lumos, QQQ with MRM method)Demonstrated expertise in bioanalytical method development and validation for small and large moleculesPerform intact and subunit protein mass spectrometry analysis, including characterization of monoclonal antibodies, fusion proteins, and bispecific/trispecific biologicsStrong working knowledge biochemical assays (enzyme assays, colorimetric assays).Hands-on experience with a range of chromatography techniques RP-HPLC, SEC, HILIC, nanoLC, microLC).Proficient in wet lab sample preparation techniques (SPE, IP, LLE)

Work Environment:

Laboratory-based position (based in Cambridge)Fast-paced environmentCollaboration with cross-functional R&D and bioanalytical teams.

LSNJN1414859AB_1750191220 To Apply for this Job Click Here