The Vilar Lab is a translational laboratory research program focused on the identification of new genes cooperating in colorectal carcinogenesis in order to identify novel drug targets, and the development of cancer chemoprevention/interception regimens that can be rapidly translated to the clinic. In this Research Intern role, we will focus on two areas: 1.) a Multi-omics project integrating DNA methylation data, RNA-seq, and TCR-seq to comprehensively evaluate how long-term exercise intervention reshapes the immune and epigenetic landscape in Lynch Syndrome carriers, with the goal of uncovering molecular mechanisms underlying cancer prevention; and 2.) applying machine learning-based classification models to identify T-cell receptor (TCR) repertoire signatures associated with Lynch Syndrome carriers harboring variants of uncertain significance (VUS), aiming to improve risk stratification and support clinical interpretation of these variants. *LEARNING OBJECTIVES* This 6-month Research Intern role will have the following objectives: • Analysis of TCRsequencing data from Lynch Syndrome participants in an excercise clinical trial • Analysis of TCRsequencing data in genetic testing recipients with germline VUS in MMR genes to build a model to reclassify genetic variants • Computational Analysis of multi-omics data • Writing manuscripts and preparing presentations of research results *ELIGIBILITY REQUIREMENTS* MS degree *POSITION INFORMATION* 07/25/2025