The Manual Ion Channel Testing group is responsible for evaluating test article effects on ion channels in vitro. Personnel are responsible for operating and maintaining manual patch clamp electrophysiology workstations. Validated hardware and software systems are used to collect and analyze data under regulated (GLP) or non-regulated conditions. The group prepares, collects and transfers test article formulation samples to the CLE analytical chemistry unit (or other appropriate laboratory) for concentration verification and homogeneity analyses, and is responsible for interpretation and reporting of data outcomes.