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At Roche, we are working to make next-generation sequencing simple and accessible enough for routine use. By accelerating clinical research, streamlining workflows, and expanding assay menus, we are broadening access to genomic data and lowering barriers to adoption. From robust sample isolation and preparation tools to novel sequencing technology and advanced bioinformatics, we are developing differentiated, highly integrated end-to-end solutions for next-generation sequencing, resulting in a sample in, result out workflow.

Our Systems Technology Group, a part of Roche Sequencing Solutions, is focused on creating and advancing technologies to significantly enhance DNA sequencing workflows. We are seeking an accomplished Principal Scientist II, Sequencing Workflow Automation Technologies, to lead the research and early development of our next-generation sample preparation and sequencing platforms. This is a critical, hands-on leadership role for a scientist who is passionate about pioneering new technologies and can bridge the gaps between complex molecular biology, chemistry and cutting-edge instrumentation. As a prominent technical leader and multidisciplinary expert, you will oversee sub-system and platform development—transforming early-stage concepts into robust, fully integrated sequencing solutions.

The Opportunity

You will serve as the team's primary subject matter expert in molecular biology, enzymology, assay development and sequencing.

You will define requirements, invent, prototype, characterize and develop novel devices, systems and workflows for next-generation sequencing applications, with a strong focus on automation and miniaturization using microfluidics and other advanced technologies.

You will lead the effort to port complex biological and chemical workflows onto early-stage instruments, breadboards, and fixtures with complex fluidic systems.

You will design and execute rigorous experiments to optimize system and instrument performance and drive troubleshooting efforts for assay and workflow performance issues on-instrument, collaborating closely with hardware and software engineers. 

You will analyze results and complex data sets, author technical reports, generate intellectual property, and communicate findings and progress to the team, the organization and senior leadership.

You will identify and champion new technological opportunities, contributing to the strategic direction of the R&D organization.

You will help build and lead a high-performing team, mentoring scientists and engineers, championing a systems-level approach to problem-solving and fostering a culture of scientific rigor and innovation.
 

This is an on-site position based in Santa Clara, CA.
Relocation benefits are not being offered for this role.

Who You Are:

(Required)

You have a PhD in Biophysics, Molecular Biology, Biochemistry, Bioengineering, or a related discipline with 7+ years of relevant industry experience; OR a Master's degree with 8+ years of relevant industry experience; OR a Bachelor's degree with 10+ years of relevant industry experience.

You have demonstrated deep, hands-on expertise in molecular biology, particularly with NGS library prep, enzymology, and nucleic acid characterization.

You have significant industry experience successfully implementing molecular biology assays or sequencing workflows on breadboards, fixtures or prototype instruments with complex fluidics or on highly integrated microfluidic devices. 

You have demonstrated a strong ability to troubleshoot complex integrated systems, identifying and resolving issues that span molecular biology, chemistry, hardware, consumables and software.

You have significant experience writing custom scripts for experimental hardware control, automation and data analysis.

You have demonstrated a high degree of motivation, ingenuity, and resourcefulness to solve problems, invent new technology and develop cutting-edge products in a fast-paced, ambiguous R&D environment; You have demonstrated the ability to lead projects and mentor others.

You have demonstrated strong interpersonal and communication skills with the ability to communicate technical knowledge in a clear and understandable manner; you excel at problem-solving skills and the ability to work under ambiguous situations

You have excellent organizational skills, including the ability to efficiently evaluate, prioritize and handle multiple changing projects and priorities; you complete work in a timely, accurate and thorough manner; You work with a sense of urgency, optimism and natural scientific/engineering curiosity
 

Who You Are:

Preferred)

You have direct experience with microfluidic systems, including design, microfabrication, and programming/control

You have experience leading multi-disciplinary technical teams, managing direct reports and developing talent

You have a strong record of innovation, demonstrated by publications and patents.

You have demonstrated proficiency with standard bioinformatics pipelines and tools for genomic analysis 

You have experience with Design of Experiments (DOE) and statistical process control (SPC).

You have a desire to learn and be challenged, to always seek out new challenges, and to challenge the status quo
 

The expected salary range for this position based on the primary location of Santa Clara, CA is $125,500 - $233,500.  Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law.  A discretionary annual bonus may be available based on individual and Company performance. 

This position also qualifies for the benefits detailed at the link provided below.

Benefits

A healthier future drives us to innovate. Together, more than 100’000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact.

Let’s build a healthier future, together.

Roche is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.

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