At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com **Job Function:** Discovery & Pre-Clinical/Clinical Development **Job Sub** **Function:** Translational Discovery & Development Biomarkers **Job Category:** Scientific/Technology **All Job Posting Locations:** Spring House, Pennsylvania, United States of America **Job Description:** About Innovative Medicine Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at https://www.jnj.com/innovative-medicine About Immunology Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Our Immunology team leads in the development of transformational medicines for immunological disorders and illnesses. You can influence where medicine is going by restoring health to millions of people living with immune diseases. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. We are searching for the best talent for a Principal Scientist, Translational Sciences (TS), Respiratory to be in Spring House, PA or Cambridge, MA. Translational Sciences and Medicine (TSM) is an integrated group of scientists composed of a clinical Translational Medicine (TM) team which conducts early clinical development and experimental medicine studies, and a Translational Sciences (TS) team which uses human based data and tissues to support the end to end portfolio. TS has a broad remit stretching from support of discovery with human data to support target selection, through development of novel decision- making biomarkers for early phase clinical trials, target-centric indication sequencing and prioritization, and biomarker support of regulatory filings. The group has expertise in biomarker development, disease biology research and in the application of immunology and data science technologies to support drug discovery and development. This position is within the Immunology Translational Sciences group and requires a highly motivated and skilled candidate to drive the translational research of innovative therapies across respiratory immune-mediated diseases. The Principal Scientist will be responsible for the development and implementation of high caliber biomarker plans, assay development & validation and associated data generation from early clinical studies. The successful candidate will contribute to the group’s strategic direction. Activities include partnering with Discovery and clinical teams to mine preclinical, clinical, and molecular data to characterize pathways of interests, patient endotypes and develop and validate patient stratification hypotheses and biomarker-based endpoint strategies translated into clinical assays. The candidate will ensure delivery of completed data and analyses in support of key program milestones and drive technical excellence in translational science and biomarker research. Furthermore, the candidate will partner with cross-functional teams to engage in interactions with external experts and academic institutions to advance the respiratory immunology portfolio. Recent lab-based experience in T2 and non-T2 immune cell analysis and patient sample analysis relevant to asthma and COPD (e.g. sputum) is highly relevant. The successful candidate will utilize a full suite of advanced technologies to enable cutting edge research and key activities will include leading biomarker discovery efforts, assay development/validation, respiratory indication sample analysis and research and may involve laboratory supervision. Finally, the Principal Scientist may serve as a Translational Science Program Lead for preclinical or early clinical respiratory programs. **Key** **responsibilities:** + Design and execution of translational strategies and biomarker assays integrating both disease and pathway approaches. Perform and oversee lab experimental execution to drive science forward + Serve as a respiratory disease subject-matter expert within Immunology Translational Sciences + Represent TS on program discovery and development teams and collaborate with Discovery and Translational Medicine on the development and implementation of clinical biomarker and patient segmentation strategies. + Communicate clearly study results and guide stakeholders in applying those results to making strategic decisions + Lead internal and external collaborations to increase team capabilities or address a strategic need + Take initiative to identify, pilot and internalize emerging technical approaches that may drive increased value for portfolio execution + Prepare and/or direct the preparation and review of protocols, clinical study reports and translational science sections of Translational plans, IBs, INDs, abstracts, manuscripts, and technical reports + Deliver on study milestones and commitments and foster a collaborative, creative, and rigorous culture of scientific discovery. **Requirements:** + Ph.D. in Immunology, Pharmacology or Molecular Biology with a minimum of 6 years of industry and/or translational research experience with a strong record of innovation required. + Training in Immunology and ideally Respiratory disease and strongly preferred. + Immune cell biology expert able to apply skills, theoretical knowledge, and experience to provide scientific direction and approach to projects and challenges. + Experience in translational research, including biomarker assay development and validation, clinical sample analysis, patient stratification in the industry setting is strongly preferred + Project leadership experience in a matrixed environment is strongly preferred + Experience gaining biological insights using translational and biomarker high dimensional biological data (e.g., flow cytometry, proteomics, transcriptomics) is preferred + Strong communication skills and the ability to effectively navigate and prioritize in a dynamic work environment are required + Self-motivated, creative, and focused; able to work within a team and to collaborate with colleagues to achieve program goals. Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act. Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, please email the Employee Health Support Center (ra-employeehealthsup@its.jnj.com) or contact AskGS to be directed to your accommodation resource. \#LI-Hybrid \#LI-Onsite