At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https://www.jnj.com **Job Function:** Discovery & Pre-Clinical/Clinical Development **Job Sub** **Function:** Biological Research **Job Category:** Scientific/Technology **All Job Posting Locations:** Cambridge, Massachusetts, United States of America, Spring House, Pennsylvania, United States of America **Job Description:** **About Innovative Medicine:** Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow. Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way. Learn more at https://www.jnj.com/innovative-medicine **We are searching for the best talent for a Principal Scientist, Muscle Biology - Aging & Metabolism to be in Spring House, PA or Cambridge, MA.** **Purpose:** The Principal Scientist plays a pivotal role in shaping drug discovery and translational research strategies to address aging-related degenerative diseases. This position leverages deep expertise in muscle biology to accelerate therapeutic development for conditions such as cardiovascular disease, thrombosis, and sarcopenia. Additionally, the role contributes to J&J therapeutic initiatives across neuroscience, immunology, and oncology. **You will be responsible for:** • Provide scientific leadership and drug discovery expertise in skeletal, cardiac, and smooth muscle biology, driving innovation in therapeutic approaches for age-related diseases. • Proficiency in in vivo and in vitro studies execution and animal models expertise in age-related pathogenesis is essential. • Support strategic collaborations across J&J’s Cross-Therapeutic Area (TA) and MedTech teams, leveraging interdisciplinary expertise to accelerate biomarker and therapeutic development. • Support the evaluation of early- and late-stage assets, guiding translational strategies for novel and repurposed candidates. • Foster strong partnerships across internal and external teams, including biologists, technical experts, clinicians, and external research collaborators to advance therapeutic programs. • Build and maintain strong collaborations within the TA (TA R&D, Clinical Development, DPDS) and partnering functions (Regulatory, Global Development, Medical Affairs, Commercial). **Qualifications / Requirements:** **Education:** • Bachelor’s degree is required • Master’s degree or PhD is highly preferred **Required:** • Minimum of 8-10 years’ experience working in muscle biology and metabolism in the Pharmaceutical/Biotechnology industry, or Academia • Excellent communication skills • Excellent knowledge of standard office software (e.g., Outlook, MS office, etc.,) and other computer systems and technologies (e.g., Zoom/Teams, SharePoint, etc.) • Ability to work effectively independently and collaborate in a global team environment • Ability and willingness to work in a global matrix environment with cross-functional, international teams • Ability to think dynamically, with a strong attention to detail and problem-solving abilities • Strong publication track record • Travel up to 10% of the time (domestic and international), defined by business needs. **Preferred:** • Previous project leadership in muscle biology The anticipated base pay range for this position in the US is $137,000 to $235,750. The Company maintains highly competitive, performance-based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporation’s performance over a calendar/ performance year. Bonuses are awarded at the Company’s discretion on an individual basis. Employees and/or eligible dependents may be eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance. Employees may be eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)). Employees are eligible for the following time off benefits: • Vacation - up to 120 hours per calendar year • Sick time - up to 40 hours per calendar year; for employees who reside in the State of Washington - up to 56 hours per calendar year • Holiday pay, including Floating Holidays - up to 13 days per calendar year • Work, Personal and Family Time - up to 40 hours per calendar year For additional general information on company benefits, please go to: https://www.careers.jnj.com/employee-benefits This job posting is anticipated to close on May 20, 2025. The Company may however extend this time-period, in which case the posting will remain available on https://www.careers.jnj.com to accept additional applications. Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act. Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, please email the Employee Health Support Center (ra-employeehealthsup@its.jnj.com) or contact AskGS to be directed to your accommodation resource. \#Li-Onsite **The anticipated base pay range for this position is :** $137,000-$235,750 Additional Description for Pay Transparency: The Company maintains highly competitive, performance-based compensation programs. Under current guidelines, this position is eligible for an annual performance bonus in accordance with the terms of the applicable plan. The annual performance bonus is a cash bonus intended to provide an incentive to achieve annual targeted results by rewarding for individual and the corporation’s performance over a calendar/performance year. Bonuses are awarded at the Company’s discretion on an individual basis. Employees and/or eligible dependents may be eligible to participate in the following Company sponsored employee benefit programs: medical, dental, vision, life insurance, short- and long-term disability, business accident insurance, and group legal insurance. Employees may be eligible to participate in the Company’s consolidated retirement plan (pension) and savings plan (401(k)). This position is eligible to participate in the Company’s long-term incentive program. Employees are eligible for the following time off benefits: Vacation – up to 120 hours per calendar year Sick time - up to 40 hours per calendar year; for employees who reside in the State of Washington – up to 56 hours per calendar year Holiday pay, including Floating Holidays – up to 13 days per calendar year of Work, Personal and Family Time - up to 40 hours per calendar year Additional information can be found through the link below. http://www.careers.jnj.com/employee-benefits The compensation and benefits information set forth in this posting applies to candidates hired in the United States. Candidates hired outside the United States will be eligible for compensation and benefits in accordance with their local market.