At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Senior Advisor Biotransformation

The Biotransformation group within the multidisciplinary DMPK organization at Eli Lilly and Company is seeking a candidate to lead and implement biotransformation studies in drug discovery and development. The selected candidate will be responsible for the conduct and oversight of in vivo and in vitro metabolism packages, investigations, interpret results, propose/complete biotransformation experiments to solve important mechanistic biotransformation questions and communicate effectively with DMPK, project teams and management. Duties will include oversight/guidance of external (CRO) metabolism studies, performance of in-house non-routine laboratory work and collaboration across various DMPK fields. We are seeking a candidate with expertise in radiolabel studies, hands-on experience performing in vivo and in vitro biotransformation studies, including mass spectrometry, structure identification, sample extraction and analytical method development. 

Job Responsibilities

Independently design, conduct, troubleshoot and provide oversight of “cold” and radiolabeled in vitro and in vivo preclinical and clinical biotransformation studies for small molecules and new modalities (i.e. peptides).Use mass spectrometry to assess in vitro and in vivo biotransformation liabilities to inform drug design.Design, conduct and guide critical problem focused experiments involving sample extraction, separation techniques, LC/MS and radiometric metabolite profiling for the identification and quantification of drug candidates and metabolites from in vitro and in vivo biological matrices.Evaluate and implement innovative technologies and aid in developing strategies to evolve biotransformation capabilities within the department.Integrate data across teams to create a rational interpretation of drug metabolism/clearance.Mentor and supervise junior scientific personnel as needed.Apply regulatory guidance in biotransformation (ie. MIST, metabolite DDI, reactive metabolites).Work collaboratively in a fast-paced work environment collaborating both internally and externally