Work Your Magic with us! Start your next chapter and join MilliporeSigma.

 

Ready to explore, break barriers, and discover more? We know you’ve got big plans – so do we! Our colleagues across the globe love innovating with science and technology to enrich people’s lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of people, customers, patients, and planet. That's why we are always looking for curious minds that see themselves imagining the unimaginable with us.  

 

This role does not offer sponsorship for work authorization. External applicants must be eligible to work in the US. 

 

Your Role:

The Indianapolis manufacturing site is a contract manufacturing site that produces complex drug product formulations for sterile injectables with specialization in LNP and Liposomes. Reporting to the Site Head, the Head of Project Management Office will manage a team of project managers and operational excellence that oversee site-wide facility projects focusing on capital improvement, digitization, and process improvement projects that enhance the performance of the site. The primary role will be to serve as the Site Project Management Office (PMO) Lead overseeing the governance, execution, and strategic alignment of all site-level projects, ensuring consistent delivery, resource optimization, and cross-functional coordination across the project portfolio. Additionally, this role serves as the leader of the Operational Excellence program, responsible for driving continuous improvement initiatives, implementing Lean and Six Sigma methodologies, and leading performance optimization efforts to enhance efficiency, quality, and operational scalability across the site. He/she will be a key member of the site leadership team driving strategic direction to develop and implement business initiatives, site plans, projects and key global strategies.

 

Key Responsibilities:

 

PMO

Lead the establishment and governance of the site-level PMO, ensuring consistent project management standards, tools, and reporting mechanisms.Own and manage the end-to-end Project Portfolio Management (PPM) process – from intake and prioritization through execution and benefits realization Work with Site Leadership to align initiatives with business strategy, operational readiness, and site scalability.Provide executive-level updates, risk assessments, and decision support for key cross-functional programs.Collaborate across sites with other Site PMO Leads and Project Managers to provide global updates on project performance and share best practices that can be brought back and applied at the site.

 

Operational Excellence

Develop and execute the site’s OpEx strategy, embedding Lean, Six Sigma, and continuous improvement methodologies across all departments.Lead value stream mapping, root cause analysis, and Kaizen events to address systemic challenges and improve key KPIs.Build and mentor a high-performing OpEx team; serve as a coach to functional leaders on problem-solving and performance optimization.Collaborate with other Site Operational Excellence Leads to provide global updates on project performance and share best practices that can be brought back and applied at the site.

 

Who You Are

 

Minimum Qualifications:

Bachelor’s degree in Science, Engineering, Operations, Business, or related field15+ years of experience in project/program management, operations or engineeringPMP or PgMP certificationExperience in life sciences, pharmaceuticals, manufacturing, or other complex regulated environmentsExcellent communication, stakeholder engagement, and leadership presence

 

Preferred Qualifications:

Background in managing large capital projects or facility expansionsDeep understanding of Lean, Six Sigma Green Belt (Black Belt preferred), and continuous improvement frameworksFamiliarity with BCM best practices and regulatory expectations in manufacturing or regulated environmentsExperience leading site-level transformation effortsExperience in life sciences, pharmaceuticals, manufacturing, or other complex regulated environmentsStrong organizational resilience and risk management mindsetAbility to influence at all levels, from floor operators to senior executives

 

What we offer: We are curious minds that come from a broad range of backgrounds, perspectives, and life experiences. We believe that this variety drives excellence and innovation, strengthening our ability to lead in science and technology. We are committed to creating access and opportunities for all to develop and grow at your own pace. Join us in building a culture of inclusion and belonging that impacts millions and empowers everyone to work their magic and champion human progress!

 

Apply now and become a part of a team that is dedicated to Sparking Discovery and Elevating Humanity!