**Use Your Power for Purpose** This Senior Principal Scientist position will be a strong scientific and leadership role within the Early Formulation Science and Drug Delivery (EFS-DD) group, supporting early-stage drug and drug product design, biopharmaceutics understanding and early clinical drug delivery strategy of new small molecules.. The selected candidate will interface with multi-disciplinary research project teams and cross functional management to provide guidance, input and direction on molecular design, dosage form design and biopharmaceutics aspects of pre-clinical and clinical candidate development. The role will also focus on developing and demonstrating leadership and drug delivery strategy skills within the Drug Product Design and Supply department which functions as part of the larger Pharmaceutical Sciences division. **ROLE SUMMARY** This Senior Principal Scientist position will be a strong scientific leadership role within the Early Formulation Science and Drug Delivery (EFS-DD) group, supporting early-stage drug and drug product design, biopharmaceutics understanding and early clinical drug delivery strategy of new small molecules within the Internal Medicine and Immunology and Inflammation therapeutic areas. The selected candidate will interface with multi-disciplinary research project teams to provide guidance, input and direction on molecular design, dosage form design and biopharmaceutics aspects of pre-clinical and clinical candidate development. The role will also focus on developing and demonstrating leadership and drug delivery strategy skills within the Drug Product Design and Supply department which functions as part of the larger Pharmaceutical Sciences division. Key activities/abilities include: + Understanding of connectivity of molecular structure, solution kinetics, thermodynamics, diffusion and permeation of molecules across membranes + Strong fundamental understanding of molecular and supramolecular interactions of small molecules in aqueous environments + Ability and interest to understand and probe molecular/supramolecular interactions of small molecules in common enabling drug delivery technologies; desire to optimize system properties to achieve required delivery profiles for pre-clinical and clinical studies + Efficient application of existing advanced modeling and simulation tools for predictive performance of oral absorption and systemic exposure (pharmacokinetics) in pre-clinical and clinical studies + Development and advancement of the concepts of early translational biopharmaceutics with a focus to improve predictive capabilities by linking in vitro drug and drug product performance attributes to in vivo performance attributes + Lead matrix teams of lab scientists and insourced workers to deliver portfolio and initiative breakthroughs + Lead scientific strategies and set direction for advances in oral, small molecule drug delivery + Maintain an awareness of and contribute to current relevant scientific literature + Conduct novel scientific research and present significant findings via internal and external presentations or publications **ROLE RESPONSIBILITIES** + EFS-DD leader will provide scientific leadership and strategic direction for the fundamental understanding of key connectivity of molecular structure, solution and diffusion behavior and permeation characteristics to enable optimal drug and drug delivery systems design + Integrates pharmaceutics, physical organic chemistry, biophysical chemistry, supramolecular chemistry and fundamental biopharmaceutics principles into drug candidate screening and design, formulation design and ultimately project direction + Teach, mentor and coach' colleagues across the Pfizer organization + Cultivates sustainable and effective relationships with internal partners and stakeholders, i.e., partner lines in Medicine Design, PharmSci Small Molecule (PSSM), Clinical Pharmacology (ClinPharm), Drug Safety (DSRD), relevant Research Units, and Pharmacokinetics, Dynamics, and Metabolism (PDM) + Advances scientific research and expands capability in the areas of molecular design-drug delivery, early biopharmaceutics and drug formulation **BASIC QUALIFICATIONS** + PhD in Pharmaceutics, Physical Chemistry, Physical Organic Chemistry, Biophysical Chemistry, Medicinal Chemistry or related discipline with 5-10 years relevant experience in drug delivery, or BS/MS in Pharmaceutics, Physical Chemistry, Physical Organic Chemistry, Biophysical Chemistry or related discipline with a minimum of 10-12 years relevant pharmaceutics industry experience in small molecule drug product design. + Knowledge in biology/pharmacology/drug discovery /drug delivery up to Proof of Concept (POC) studies. + Small molecule formulation and/or early Medicinal Chemistry, Biopharmaceutics, Pharmacokinetics background, and a strong record of scientific achievement + Experience in using and interpreting biophysical modeling, physicochemical (solubility & dissolution) and biological (passive, transporter mediated, efflux) transport phenomena, design, interpretation, and use of in vitro experiments, or in vivo/in vitro drug metabolism studies, and interpretation of pre-clinical exposure data for the design and selection of new small molecule drug candidates and drug delivery systems + A strong interest and motivation to learn and implement new technologies and concepts. + A strong interest in matrix leadership and development of management skills + Extensive practical experience working within cross-disciplinary teams and achieving results in a matrix environment. + Excellent organizational and communication (oral and written) skills. + The ability to work independently, as well as collaboratively. **PREFERRED QUALIFICATIONS** + Proven track record of supervising, mentoring and coaching junior scientists. + Understanding of drug discovery and development concepts + Experience in actively developing and advancing scientific initiatives and external collaborations. + Medicinal Chemistry/Drug Design experience + Collaborative and effective partnering skills applied in a complex, multi-disciplinary organizational model. + High degree of self-awareness and emotional intelligence **PHYSICAL/MENTAL REQUIREMENTS** Sitting, standing, ability to perform mathematical calculations and ability to perform complex data analysis **NON-STANDARD WORK SCHEDULE, TRAVEL OR ENVIRONMENT REQUIREMENTS** Intermittent travel required between Pfizer sites in Groton, CT and La Jolla, CA Relocation support available Work Location Assignment: On Premise The annual base salary for this position ranges from $120,800.00 to $201,400.00. In addition, this position is eligible for participation in Pfizer's Global Performance Plan with a bonus target of 17.5% of the base salary and eligibility to participate in our share based long term incentive program. We offer comprehensive and generous benefits and programs to help our colleagues lead healthy lives and to support each of life's moments. Benefits offered include a 401(k) plan with Pfizer Matching Contributions and an additional Pfizer Retirement Savings Contribution, paid vacation, holiday and personal days, paid caregiver/parental and medical leave, and health benefits to include medical, prescription drug, dental and vision coverage. Learn more at Pfizer Candidate Site - U.S. Benefits | (uscandidates.mypfizerbenefits.com). Pfizer compensation structures and benefit packages are aligned based on the location of hire. The United States salary range provided does not apply to Tampa, FL or any location outside of the United States. Relocation assistance may be available based on business needs and/or eligibility. **Sunshine Act** Pfizer reports payments and other transfers of value to health care providers as required by federal and state transparency laws and implementing regulations. These laws and regulations require Pfizer to provide government agencies with information such as a health care provider's name, address and the type of payments or other value received, generally for public disclosure. Subject to further legal review and statutory or regulatory clarification, which Pfizer intends to pursue, reimbursement of recruiting expenses for licensed physicians may constitute a reportable transfer of value under the federal transparency law commonly known as the Sunshine Act. Therefore, if you are a licensed physician who incurs recruiting expenses as a result of interviewing with Pfizer that we pay or reimburse, your name, address and the amount of payments made currently will be reported to the government. If you have questions regarding this matter, please do not hesitate to contact your Talent Acquisition representative. **EEO & Employment Eligibility** Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status. Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA. Pfizer is an E-Verify employer. This position requires permanent work authorization in the United States. Pfizer endeavors to make www.pfizer.com/careers accessible to all users. If you would like to contact us regarding the accessibility of our website or need assistance completing the application process and/or interviewing, please email disabilityrecruitment@pfizer.com. This is to be used solely for accommodation requests with respect to the accessibility of our website, online application process and/or interviewing. Requests for any other reason will not be returned. Research and Development