Bioinformatician (protein engineering) Job Details | Wacker Chemie AG We use cookies to offer you the best possible website experience. Your cookie preferences will be stored in your browser’s local storage. This includes cookies necessary for the website's operation. Additionally, you can freely decide and change any time whether you accept cookies or choose to opt out of cookies to improve website's performance, as well as cookies used to display content tailored to your interests. Your experience of the site and the services we are able to offer may be impacted if you do not accept all cookies. 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Country/Region All City All Functional Area All Career Level All Employment type All Clear Select how often (in days) to receive an alert: Create Alert × Select how often (in days) to receive an alert: Apply now » Apply now + Start apply with LinkedIn + Apply Now Start + Please wait... Date: Jul 16, 2025 Location: Pilsen Company: Wacker-Chemie, s.r.o. Do you want to take responsibility and make a difference with your work? With your expertise, we can achieve great goals together. We are WACKER - Reliable. Determined. Ambitious. As one of the world's most research-intensive chemical companies, we've been making countless products that are an integral part of your everyday life possible for over 100 years. From vegan food to resource-efficient buildings to solar cells, we develop sustainable solutions that change the future. Bioinformatician – focused on protein engineering. Tasks / Repsonsibilities + Establishment of bioinformatic methods for predicting mutations in proteins with the aim of improving expression, solubility, stability, and activity. + Rational protein design, as well as AI-driven predictions to identify and evaluate potential hotspots for directed mutagenesis. + Utilization of molecular dynamics methods to identify important interaction surfaces using atomistic or coarse-grained simulations. + Development of internal workflows and toolkits for investigating protein-protein and protein-ligand interactions, e.g. Free energy determination. + Development of strategies to optimize regulatory elements (e.g. promoter and terminator regions) for targeted control of gene expression in various host organisms. + Evaluation of data from the fields of genomics, proteomics, and metabolomics to support microbiology groups. + Evaluation of principles and work with external partners/consultants, provide support for collaboration. + Proactive knowledge management regarding tools, methods, and best practices. + Close colaboration with the areas of molecular biology, protein biochemistry, and fermentation. + Documentation and presentation of results in project meetings. Qualifications / Requirements + M.Sc. or PhD degree in bioinformatics, structural biology, biochemistry, computational biology, or a related field. + Solid knowledge in the analysis of protein sequences and structures using computational expertise. + Experience in predicting and evaluating mutations concerning protein structure and function. + Knowledge in the analysis and optimization of regulatory DNA elements (promoters, terminators). + Strong skills in Python programming and Linux environments, knowledge of machine learning frameworks (e.g., PyTorch, TensorFlow) are an advantage. + Experience with cloud computing platforms (preferably Microsoft Azure). + Experience with Illumina and ONT sequencing data as well as bioinformatics NGS pipelines. + Team player, self-initiative, and a structured working style. + Strong problem-solving and analytical skills. + A passion for continuous learning and improvement. + Excellent English language skills. We offer + Competitive Salary (with yearly bonus up to 15%) + Opportunity for Future Growth and Advancement + Meal allowance of 123 CZK / day + Transport allowance of 100 CZK / day + Vacation allowance 10 000 CZK / year + Flexi Pass 20 000 CZK / year + Christmas allowance 10 000 CZK / year + 5 weeks of holiday and for every 3 years of employment plus 1 extra day of holiday 3 days of sick leave per year + Pension insurance contribution up to 4 166 CZK / month + Home office option ...and much more! ​ As an international company, we welcome the diversity of people. We consciously promote equal opportunities and a diverse, inclusive culture in our teams - this is what makes us successful. We look forward to receiving your application! Reference code: 29814 ​