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I further attest that all information I submit in my employment application is true to the best of my knowledge. **Job Description** Please note this job requires business level Japanese in speaking, writing, and reading. **_OBJECTIVES/PURPOSE:_** + Leads planning and implementation of in vitro studies to identify and characterize hit/lead molecules for SAR and subsequent in vivo pharmacology studies. + Serves as an IVP scientific lead in Japan to establish sustainable in vitro platform and its operational framework in the lab closely working with relevant functions/divisions. + Works as a global IVP leadership team member to improve probability of success of small molecule asset generation by developing and implementing efficient in vitro screening cascade. + Responsible for the generation of novel in vitro assays to support small molecule projects across therapeutic areas. + Responsible for quality of in vitro pharmacology data and assay performance. + Manages in vitro assay data pertaining to synthetic compounds and small molecule libraries + Works with external vendors to manage any in vitro pharmacology screening work conducted at CROs **_ACCOUNTABILITIES:_** + Identifies bottlenecks of small molecule programs, and develops strategic plans and methodology for in vitro studies to address key challenges + Participates in program teams as a representative of IVP and lead scientific discussion on screening methods and cascade + Develops in vitro assays and executes planned studies internally and/or externally (lead optimization support, screening for new chemotype generation, mechanistic analysis on molecular biology, primary/secondary/counter/confirmatory assay development and implementation, etc) + Organizes and manages committees for in vitro assay data management pertaining to synthetic compounds and small molecule libraries to effectively leverage internal databases achieving global harmonization + Evaluates necessity of capital investment for in vitro platform in Takeda Shonan site + Evaluates CROs for relevant services and promote their effective use + Develops talents so that internal IVP function can sustainably grow keeping up with cutting edge new technologies **_CORE ELEMENTS RELATED TO THIS ROLE:_** + Provides program team with deep scientific insights from molecular biology perspective + Develops internal capability striking balance between insourcing and outsourcing + Pursues efficiency proactively introducing automation technologies **_DIMENSIONS AND ASPECTS:_** **Technical/Functional (Line) Expertise** + Being up to date on latest pharmacology assays and data analysis + Has knowledge to utilize compound and assay databases + Miniaturization of assays in order to increase assay bandwidth + Demonstrates broad technical program knowledge + Acts as the recognized scientific resource on an aspect of a program + Demonstrates effective project management skills **Leadership** Exerts strong leadership to elevate internal scientific level of molecular biology globally + Posesses tenacious mind to achieve critical goals of the organization + Plays a pivotal role in establishing one global IVP team in close collaboration with members in other sites **Decision-making and Autonomy** + Plays a pivotal role in IVP lab operation in Takeda Shonan site + Judgement of ideal balance of internal and external resource allocation for in vitro studies **Interaction** + Interacts with broad range of stakeholders internally (e.g. Drug Discovery Unit, DMPK, Safety) and externally (CROs) + Frequently communicates with members based in Boston site **Innovation** + Maintains open mindset to adopt new innovative technologies/frameworks to achieve best practice + Not stick to historical standard + Strives to identify/generate differentiated molecules from molecular biology standpoint **Complexity** + Needs to work with diverse people from technicians to area-specific experts in interdisciplinary projects **_EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS:_** + PhD degree in a scientific discipline with 5+ years experience , or + MS with 7+ years experience, or + BS with 9+ years experience in in vitro assay development and/or molecular biology + Familiarized with both cell-based and cell-free assays including biochemical assays (e.g. binding and enzymatic assays) to evaluate small molecules + Preferably, with experience and knowledge for biophysical assays + Posses sufficient knowlege on assay material preparation such as procedures of cloning, genetic modifications of cell lines, protein expression and purification, etc. + Experiece and/or familiarity with molecular screening + Broad familiarity with overall process of preclinical research + Good command of Excel based data analysis + Good communication skill to establish good relationship with global members **Takeda Compensation and Benefits Summary:** + Allowances: Commutation, Housing, Overtime Work etc. + Salary Increase: Annually, Bonus Payment: Twice a year + Working Hours: Headquarters (Osaka/ Tokyo) 9:00-17:30, Production Sites (Osaka/ Yamaguchi) 8:00-16:45, (Narita) 8:30-17:15, Research Site (Kanagawa) 9:00-17:45 + Holidays: Saturdays, Sundays, National Holidays, May Day, Year-End Holidays etc. (approx. 123 days in a year) + Paid Leaves: Annual Paid Leave, Special Paid Leave, Sick Leave, Family Support Leave, Maternity Leave, Childcare Leave, Family Nursing Leave. + Flexible Work Styles: Flextime, Telework + Benefits: Social Insurance, Retirement and Corporate Pension, Employee Stock Ownership Program, etc. **Important Notice concerning working conditions:** + It is possible the job scope may change at the company’s discretion. + It is possible the department and workplace may change at the company’s discretion. **Locations** Fujisawa, Japan **Worker Type** Employee **Worker Sub-Type** Regular **Time Type** Full time