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Job Description

Please note this job requires business level Japanese in speaking, writing, and reading.  

 OBJECTIVES/PURPOSE:

Leads planning and implementation of in vitro studies to identify and characterize hit/lead molecules for SAR and subsequent in vivo pharmacology studies.

Serves as an IVP scientific lead in Japan to establish sustainable in vitro platform and its operational framework in the lab closely working with relevant functions/divisions.

Works as a global IVP leadership team member to improve probability of success of small molecule asset generation by developing and implementing efficient in vitro screening cascade.

Responsible for the generation of novel in vitro assays to support small molecule projects across therapeutic areas.

Responsible for quality of in vitro pharmacology data and assay performance.

Manages in vitro assay data pertaining to synthetic compounds and small molecule libraries

Works with external vendors to manage any in vitro pharmacology screening work conducted at CROs

ACCOUNTABILITIES:

Identifies bottlenecks of small molecule programs, and develops strategic plans and methodology for in vitro studies to address key challenges

Participates in program teams as a representative of IVP and lead scientific discussion on screening methods and cascade

Develops in vitro assays and executes planned studies internally and/or externally (lead optimization support, screening for new chemotype generation, mechanistic analysis on molecular biology, primary/secondary/counter/confirmatory assay development and implementation, etc)

Organizes and manages committees for in vitro assay data management pertaining to synthetic compounds and small molecule libraries to effectively leverage internal databases achieving global harmonization

Evaluates necessity of capital investment for in vitro platform in Takeda Shonan site

Evaluates CROs for relevant services and promote their effective use

Develops talents so that internal IVP function can sustainably grow keeping up with cutting edge new technologies

CORE ELEMENTS RELATED TO THIS ROLE:  

Provides program team with deep scientific insights from molecular biology perspective

Develops internal capability striking balance between insourcing and outsourcing

Pursues efficiency proactively introducing automation technologies

DIMENSIONS AND ASPECTS:

Technical/Functional (Line) Expertise

Being up to date on latest pharmacology assays and data analysis

Has knowledge to utilize compound and assay databases

Miniaturization of assays in order to increase assay bandwidth

Demonstrates broad technical program knowledge

Acts as the recognized scientific resource on an aspect of a program

Demonstrates effective project management skills

Leadership Exerts strong leadership to elevate internal scientific level of molecular biology globally

Posesses tenacious mind to achieve critical goals of the organization

Plays a pivotal role in establishing one global IVP team in close collaboration with members in other sites

Decision-making and Autonomy

Plays a pivotal role in IVP lab operation in Takeda Shonan site

Judgement of ideal balance of internal and external resource allocation for in vitro studies

Interaction

Interacts with broad range of stakeholders internally (e.g. Drug Discovery Unit, DMPK, Safety) and externally (CROs)

Frequently communicates with members based in Boston site

Innovation

Maintains open mindset to adopt new innovative technologies/frameworks to achieve best practice

Not stick to historical standard

Strives to identify/generate differentiated molecules from molecular biology standpoint

Complexity

Needs to work with diverse people from technicians to area-specific experts in interdisciplinary projects

EDUCATION, BEHAVIOURAL COMPETENCIES AND SKILLS: 

PhD degree in a scientific discipline with 5+ years experience , or

MS with 7+ years experience, or

BS with 9+ years experience in in vitro assay development and/or molecular biology

Familiarized with both cell-based and cell-free assays including biochemical assays (e.g. binding and enzymatic assays) to evaluate small molecules

Preferably, with experience and knowledge for biophysical assays

Posses sufficient knowlege on assay material preparation such as procedures of cloning, genetic modifications of cell lines, protein expression and purification, etc.

Experiece and/or familiarity with molecular screening

Broad familiarity with overall process of preclinical research

Good command of Excel based data analysis

Good communication skill to establish good relationship with global members

Takeda Compensation and Benefits Summary:

Allowances: Commutation, Housing, Overtime Work etc.

Salary Increase: Annually, Bonus Payment: Twice a year

Working Hours: Headquarters (Osaka/ Tokyo) 9:00-17:30, Production Sites (Osaka/ Yamaguchi) 8:00-16:45, (Narita) 8:30-17:15, Research Site (Kanagawa) 9:00-17:45

Holidays: Saturdays, Sundays, National Holidays, May Day, Year-End Holidays etc. (approx. 123 days in a year)

Paid Leaves: Annual Paid Leave, Special Paid Leave, Sick Leave, Family Support Leave, Maternity Leave, Childcare Leave, Family Nursing Leave.

Flexible Work Styles: Flextime, Telework

Benefits: Social Insurance, Retirement and Corporate Pension, Employee Stock Ownership Program, etc.

Important Notice concerning working conditions:

It is possible the job scope may change at the company’s discretion.

It is possible the department and workplace may change at the company’s discretion.

LocationsFujisawa, Japan

Worker TypeEmployee

Worker Sub-TypeRegular

Time TypeFull time